USP37 Antibody, FITC conjugated (PACO57274)
- SKU:
- PACO57274
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | USP37 Antibody, FITC conjugated (PACO57274) |
抗体コード: | PACO57274 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 37 protein (671-797AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1. |
シノニム: | Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37), USP37, KIAA1594 |
UniProt Protein Function: | USP37: a ubiquitin carboxyl-terminal hydrolase involved in deubiquitination. |
UniProt Protein Details: | Protein type:Protease; Ubiquitin conjugating system; EC 3.4.19.12; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 2q35 Cellular Component: nucleus Molecular Function:cysteine-type endopeptidase activity; protein binding; protein kinase binding; ubiquitin-specific protease activity Biological Process: G1/S transition of mitotic cell cycle; protein deubiquitination |
UniProt Code: | Q86T82 |
NCBI GenInfo Identifier: | 300669620 |
NCBI Gene ID: | 57695 |
NCBI Accession: | Q86T82.2 |
UniProt Secondary Accession: | Q86T82,Q2KHT2, Q53S10, Q7Z3A5, Q9HCH8, A2RUQ8, B7ZM38 B7ZM41, E9PHL3, |
UniProt Related Accession: | Q86T82 |
Molecular Weight: | 99,752 Da |
NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 37 |
NCBI Synonym Full Names: | ubiquitin specific peptidase 37 |
NCBI Official Symbol: | USP37 |
NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 37 |
UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 37 |
UniProt Synonym Protein Names: | Deubiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37 |
Protein Family: | Ubiquitin carboxyl-terminal hydrolase |
UniProt Gene Name: | USP37 |
UniProt Entry Name: | UBP37_HUMAN |