TRIP13 Antibody (PACO35710)
- SKU:
- PACO35710
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TRIP13 Antibody (PACO35710) |
抗体コード: | PACO35710 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Pachytene checkpoint protein 2 homolog protein (181-390AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO35710 at dilution of 1:100. | |
Western blot. All lanes: TRIP13 antibody at 1µg/ml + A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 49, 23 kDa. Observed band size: 49 kDa. | |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO35710 at dilution of 1:100. |
バックグラウンド: | Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation. |
シノニム: | Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13), TRIP13, PCH2 |
UniProt Protein Function: | TRIP13: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Belongs to the AAA ATPase family. PCH2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 5p15.33 Cellular Component: nucleus Molecular Function:identical protein binding; protein binding; transcription cofactor activity Biological Process: double-strand break repair; meiotic recombination; oogenesis; spermatogenesis; synaptonemal complex assembly; transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q15645 |
NCBI GenInfo Identifier: | 85541056 |
NCBI Gene ID: | 9319 |
NCBI Accession: | Q15645.2 |
UniProt Secondary Accession: | Q15645,O15324, C9K0T3, D3DTC0, |
UniProt Related Accession: | Q15645 |
Molecular Weight: | 22,084 Da |
NCBI Full Name: | Pachytene checkpoint protein 2 homolog |
NCBI Synonym Full Names: | thyroid hormone receptor interactor 13 |
NCBI Official Symbol: | TRIP13 |
NCBI Official Synonym Symbols: | 16E1BP |
NCBI Protein Information: | pachytene checkpoint protein 2 homolog |
UniProt Protein Name: | Pachytene checkpoint protein 2 homolog |
UniProt Synonym Protein Names: | Human papillomavirus type 16 E1 protein-binding protein; 16E1-BP; HPV16 E1 protein-binding protein; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13 |
UniProt Gene Name: | TRIP13 |
UniProt Entry Name: | PCH2_HUMAN |
Antibodies | ELISA Kits |
Anti-TRIP13 Antibody (CAB17357) | TRIP13 Colorimetric Cell-Based ELISA |
TRIP13 Antibody (PACO05744) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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