TP53INP1 Antibody, Biotin conjugated (PACO49241)
- SKU:
- PACO49241
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | TP53INP1 Antibody, Biotin conjugated (PACO49241) |
抗体コード: | PACO49241 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Tumor protein p53-inducible nuclear protein 1 protein (138-205AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. |
シノニム: | Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1), TP53INP1, P53DINP1 SIP |
UniProt Protein Function: | TP53INP1: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis; Tumor suppressor; Cell cycle regulation Chromosomal Location of Human Ortholog: 8q22 Cellular Component: PML body; autophagic vacuole; cytoplasmic vesicle; nucleus; cytosol Molecular Function:antioxidant activity; protein binding Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; response to heat; apoptosis; positive regulation of transcription, DNA-dependent; autophagic cell death; response to stress; cell cycle arrest; negative regulation of cell migration; positive regulation of autophagy; autophagic vacuole formation |
UniProt Code: | Q96A56 |
NCBI GenInfo Identifier: | 209180469 |
NCBI Gene ID: | 94241 |
NCBI Accession: | NP_001129205.1 |
UniProt Secondary Accession: | Q96A56,Q969R9, B2RCE5, |
UniProt Related Accession: | Q96A56 |
Molecular Weight: | 27,366 Da |
NCBI Full Name: | tumor protein p53-inducible nuclear protein 1 isoform b |
NCBI Synonym Full Names: | tumor protein p53 inducible nuclear protein 1 |
NCBI Official Symbol: | TP53INP1 |
NCBI Official Synonym Symbols: | SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B |
NCBI Protein Information: | tumor protein p53-inducible nuclear protein 1; p53-inducible p53DINP1; stress-induced protein; p53-dependent damage-inducible nuclear protein 1 |
UniProt Protein Name: | Tumor protein p53-inducible nuclear protein 1 |
UniProt Synonym Protein Names: | Stress-induced protein; p53-dependent damage-inducible nuclear protein 1 |
Protein Family: | Tumor protein p53-inducible nuclear protein |
UniProt Gene Name: | TP53INP1 |
UniProt Entry Name: | T53I1_HUMAN |