TAB3 Antibody (PACO16649)
- SKU:
- PACO16649
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TAB3 Antibody (PACO16649) |
抗体コード: | PACO16649 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human TAB3 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16649(TAB3 Antibody) at dilution 1/25. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 293T cells, Raw264.7 cells, NIH/3T3 cells, K562 cells, Jurkat cells, Primary antibody: PACO16649(TAB3 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. | |
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16649(TAB3 Antibody) at dilution 1/25. (Original magnification: x200). |
バックグラウンド: | The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. |
シノニム: | TGF-β activated kinase 1/MAP3K7 binding protein 3 |
UniProt Protein Function: | TAB3: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: Xp21.2 Cellular Component: cytoplasm; cytosol; endosome membrane; nucleoplasm; plasma membrane Molecular Function:protein binding Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; negative regulation of autophagy; stimulatory C-type lectin receptor signaling pathway |
NCBI Summary: | The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8N5C8 |
NCBI GenInfo Identifier: | 229462756 |
NCBI Gene ID: | 257397 |
NCBI Accession: | Q8N5C8.2 |
UniProt Secondary Accession: | Q8N5C8,Q6VQR0, A6NDD9, |
UniProt Related Accession: | Q8N5C8 |
Molecular Weight: | 75,599 Da |
NCBI Full Name: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
NCBI Synonym Full Names: | TGF-beta activated kinase 1/MAP3K7 binding protein 3 |
NCBI Official Symbol: | TAB3 |
NCBI Official Synonym Symbols: | NAP1; MAP3K7IP3 |
NCBI Protein Information: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
UniProt Protein Name: | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 |
UniProt Synonym Protein Names: | Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; TAK1-binding protein 3; TAB-3; TGF-beta-activated kinase 1-binding protein 3 |
Protein Family: | TGF-beta-activated kinase 1 and MAP3K7-binding protein |
UniProt Gene Name: | TAB3 |
UniProt Entry Name: | TAB3_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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