STEAP3 Antibody (PACO12520)
- SKU:
- PACO12520
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | STEAP3 Antibody (PACO12520) |
抗体コード: | PACO12520 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human STEAP3 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | STEAP family member 3;STEAP3;STMP3;TSAP6;dudlin-2 ; |
UniProt Protein Function: | STEAP3: a multi-pass membrane protein induced directly by p53. Plays an important role in facilitating exosome secretion. Enhances secretion in the DNA damage-induced p53-dependent exosomal secretory pathway. Localizes to vesicular-like structures at the plasma membrane and around the nucleus. Highly expressed in hematopoietic tissues where it localizes to the specialized endosome. An endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor. Contains a highly-conserved tyrosine-based motif that has been shown to target transmembrane proteins, including LAMP-1, LAMP-2, the TfR, and SLC11A1 to endosomes, lysosomes, and lysosome-related organelles. Facilitates the exosomal secretion of proteins such as TCTP. Interacts with BNIP3L, MYT1 and TPT1. Four human isoforms are produced by alternative splicing. Isoform 4 is also known as pHyde II. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; EC 1.16.1.-; Transporter, iron; Transporter, ion channel; Oxidoreductase; Transporter Chromosomal Location of Human Ortholog: 2q14.2 Cellular Component: multivesicular body; integral to membrane; plasma membrane; endosome membrane Molecular Function:protein binding; metal ion binding; cupric reductase activity; ferric-chelate reductase activity Biological Process: apoptosis; cellular iron ion homeostasis; protein secretion; transferrin transport; copper ion import; cell cycle; transmembrane transport Disease: Anemia, Hypochromic Microcytic, With Iron Overload 2 |
NCBI Summary: | This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
UniProt Code: | Q658P3 |
NCBI GenInfo Identifier: | 146325737 |
NCBI Gene ID: | 55240 |
NCBI Accession: | Q658P3.2 |
UniProt Secondary Accession: | Q658P3,Q4VBR2, Q4ZG36, Q53SQ8, Q7Z389, Q86SF6, Q8NEW6 Q8TDP3, Q8TF03, Q9NVB5, A8K6E3, |
UniProt Related Accession: | Q658P3 |
Molecular Weight: | 488 |
NCBI Full Name: | Metalloreductase STEAP3 |
NCBI Synonym Full Names: | STEAP family member 3, metalloreductase |
NCBI Official Symbol: | STEAP3 |
NCBI Official Synonym Symbols: | STMP3; TSAP6; AHMIO2; dudlin-2 |
NCBI Protein Information: | metalloreductase STEAP3; pHyde; hTSAP6; hpHyde; dudlin 2; dudulin 2; dudulin-2; 1010001D01Rik; tumor suppressor pHyde; six transmembrane prostate protein 3; tumor suppressor-activated pathway protein 6; six-transmembrane epithelial antigen of prostate 3 |
UniProt Protein Name: | Metalloreductase STEAP3 |
UniProt Synonym Protein Names: | Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde |
Protein Family: | Metalloreductase |
UniProt Gene Name: | STEAP3 |
UniProt Entry Name: | STEA3_HUMAN |