Description
抗体名: | STEAP3 Antibody, Biotin conjugated (PACO36385) |
抗体コード: | PACO36385 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Metalloreductase STEAP3 protein (1-207AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. |
シノニム: | Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde), STEAP3, TSAP6 |
UniProt Protein Function: | STEAP3: a multi-pass membrane protein induced directly by p53. Plays an important role in facilitating exosome secretion. Enhances secretion in the DNA damage-induced p53-dependent exosomal secretory pathway. Localizes to vesicular-like structures at the plasma membrane and around the nucleus. Highly expressed in hematopoietic tissues where it localizes to the specialized endosome. An endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor. Contains a highly-conserved tyrosine-based motif that has been shown to target transmembrane proteins, including LAMP-1, LAMP-2, the TfR, and SLC11A1 to endosomes, lysosomes, and lysosome-related organelles. Facilitates the exosomal secretion of proteins such as TCTP. Interacts with BNIP3L, MYT1 and TPT1. Four human isoforms are produced by alternative splicing. Isoform 4 is also known as pHyde II. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; EC 1.16.1.-; Transporter, iron; Transporter, ion channel; Oxidoreductase; Transporter Chromosomal Location of Human Ortholog: 2q14.2 Cellular Component: multivesicular body; integral to membrane; plasma membrane; endosome membrane Molecular Function:protein binding; metal ion binding; cupric reductase activity; ferric-chelate reductase activity Biological Process: apoptosis; cellular iron ion homeostasis; protein secretion; transferrin transport; copper ion import; cell cycle; transmembrane transport Disease: Anemia, Hypochromic Microcytic, With Iron Overload 2 |
NCBI Summary: | This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
UniProt Code: | Q658P3 |
NCBI GenInfo Identifier: | 146325737 |
NCBI Gene ID: | 55240 |
NCBI Accession: | Q658P3.2 |
UniProt Secondary Accession: | Q658P3,Q4VBR2, Q4ZG36, Q53SQ8, Q7Z389, Q86SF6, Q8NEW6 Q8TDP3, Q8TF03, Q9NVB5, A8K6E3, |
UniProt Related Accession: | Q658P3 |
Molecular Weight: | 488 |
NCBI Full Name: | Metalloreductase STEAP3 |
NCBI Synonym Full Names: | STEAP family member 3, metalloreductase |
NCBI Official Symbol: | STEAP3 |
NCBI Official Synonym Symbols: | STMP3; TSAP6; AHMIO2; dudlin-2 |
NCBI Protein Information: | metalloreductase STEAP3; pHyde; hTSAP6; hpHyde; dudlin 2; dudulin 2; dudulin-2; 1010001D01Rik; tumor suppressor pHyde; six transmembrane prostate protein 3; tumor suppressor-activated pathway protein 6; six-transmembrane epithelial antigen of prostate 3 |
UniProt Protein Name: | Metalloreductase STEAP3 |
UniProt Synonym Protein Names: | Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde |
Protein Family: | Metalloreductase |
UniProt Gene Name: | STEAP3 |
UniProt Entry Name: | STEA3_HUMAN |