SMC5 Antibody, Biotin conjugated (PACO58267)
- SKU:
- PACO58267
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | SMC5 Antibody, Biotin conjugated (PACO58267) |
抗体コード: | PACO58267 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome. |
シノニム: | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5), SMC5, KIAA0594 SMC5L1 |
UniProt Protein Function: | SMC5: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. Belongs to the SMC family. SMC5 subfamily. |
UniProt Protein Details: | Protein type:DNA replication Chromosomal Location of Human Ortholog: 9q21.12 Cellular Component: nucleoplasm; PML body; chromosome, telomeric region; cell junction; nucleus Molecular Function:protein binding; ATP binding Biological Process: mitosis; positive regulation of maintenance of mitotic sister chromatid cohesion; cell division; telomere maintenance via recombination; positive regulation of mitotic metaphase/anaphase transition; double-strand break repair via nonhomologous end joining; double-strand break repair via homologous recombination |
UniProt Code: | Q8IY18 |
NCBI GenInfo Identifier: | 122070387 |
NCBI Gene ID: | 23137 |
NCBI Accession: | Q8IY18.2 |
UniProt Related Accession: | Q8IY18 |
Molecular Weight: | |
NCBI Full Name: | Structural maintenance of chromosomes protein 5 |
NCBI Synonym Full Names: | structural maintenance of chromosomes 5 |
NCBI Official Symbol: | SMC5 |
NCBI Official Synonym Symbols: | SMC5L1 |
NCBI Protein Information: | structural maintenance of chromosomes protein 5 |
UniProt Protein Name: | Structural maintenance of chromosomes protein 5 |
Protein Family: | SMC5-SMC6 complex localization factor protein |
UniProt Gene Name: | SMC5 |
UniProt Entry Name: | SMC5_HUMAN |