SIRT4 Antibody (PACO20470)
- SKU:
- PACO20470
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SIRT4 Antibody (PACO20470) |
抗体コード: | PACO20470 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human SIRT4 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO20470(SIRT4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20470(SIRT4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. |
シノニム: | sirtuin 4 |
UniProt Protein Function: | SIRT4: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down- regulates insulin secretion. Has no detectable protein deacetylase activity. Belongs to the sirtuin family. Class II subfamily. |
UniProt Protein Details: | Protein type:Tumor suppressor; Mitochondrial; Deacetylase; EC 2.4.2.-; EC 3.5.1.- Chromosomal Location of Human Ortholog: 12q Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:biotinidase activity; NAD+ ADP-ribosyltransferase activity; protein binding Biological Process: chromatin silencing; glutamine metabolic process; negative regulation of fatty acid oxidation; negative regulation of insulin secretion; positive regulation of lipid biosynthetic process; protein amino acid ADP-ribosylation; response to DNA damage stimulus |
NCBI Summary: | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y6E7 |
NCBI GenInfo Identifier: | 38258657 |
NCBI Gene ID: | 23409 |
NCBI Accession: | Q9Y6E7.1 |
UniProt Secondary Accession: | Q9Y6E7,O43346, Q32M33, |
UniProt Related Accession: | Q9Y6E7 |
Molecular Weight: | 35,188 Da |
NCBI Full Name: | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
NCBI Synonym Full Names: | sirtuin 4 |
NCBI Official Symbol: | SIRT4 |
NCBI Official Synonym Symbols: | SIR2L4 |
NCBI Protein Information: | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
UniProt Protein Name: | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
UniProt Synonym Protein Names: | NAD-dependent ADP-ribosyltransferase sirtuin-4 |
Protein Family: | NAD-dependent protein deacylase |
UniProt Gene Name: | SIRT4 |
UniProt Entry Name: | SIR4_HUMAN |
Antibodies | ELISA Kits |
Anti-SIRT4 Antibody (CAB15800) | Human NAD-dependent ADP-ribosyltransferase sirtuin-4 (SIRT4) ELISA Kit |
Anti-SIRT4 Antibody (CAB7585) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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