SESN1 Antibody, FITC conjugated (PACO51948)
- SKU:
- PACO51948
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | SESN1 Antibody, FITC conjugated (PACO51948) |
抗体コード: | PACO51948 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Sestrin-1 protein (224-337AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed (By similarity). |
シノニム: | Sestrin-1 (EC 1.11.1.15) (p53-regulated protein PA26), SESN1, PA26 SEST1 |
UniProt Protein Function: | SESN1: Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth. Belongs to the sestrin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q21 Cellular Component: nucleus Biological Process: negative regulation of cell proliferation; regulation of protein kinase B signaling cascade; cell cycle arrest; response to DNA damage stimulus |
NCBI Summary: | This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q9Y6P5 |
NCBI GenInfo Identifier: | 13633953 |
NCBI Gene ID: | 27244 |
NCBI Accession: | Q9Y6P5.2 |
UniProt Secondary Accession: | Q9Y6P5,Q2M2B7, Q5T316, Q9NV00, Q9UPD5, Q9Y6P6, |
UniProt Related Accession: | Q9Y6P5 |
Molecular Weight: | 49,624 Da |
NCBI Full Name: | Sestrin-1 |
NCBI Synonym Full Names: | sestrin 1 |
NCBI Official Symbol: | SESN1 |
NCBI Official Synonym Symbols: | PA26; SEST1 |
NCBI Protein Information: | sestrin-1; p53 activated gene 26; p53 regulated PA26 nuclear protein |
UniProt Protein Name: | Sestrin-1 |
UniProt Synonym Protein Names: | p53-regulated protein PA26 |
Protein Family: | Sestrin |
UniProt Gene Name: | SESN1 |
UniProt Entry Name: | SESN1_HUMAN |