SERPING1 Antibody, HRP conjugated (PACO49999)
- SKU:
- PACO49999
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | SERPING1 Antibody, HRP conjugated (PACO49999) |
抗体コード: | PACO49999 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Plasma protease C1 inhibitor protein (23-300AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. |
シノニム: | Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1), SERPING1, C1IN C1NH |
UniProt Protein Function: | SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11q12.1 Cellular Component: extracellular space; extracellular region Molecular Function:serine-type endopeptidase inhibitor activity; protein binding Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; complement activation, classical pathway; blood coagulation, intrinsic pathway; aging Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I |
NCBI Summary: | This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008] |
UniProt Code: | P05155 |
NCBI GenInfo Identifier: | 124096 |
NCBI Gene ID: | 710 |
NCBI Accession: | P05155.2 |
UniProt Secondary Accession: | P05155,Q16304, Q547W3, Q59EI5, Q7Z455, Q96FE0, Q9UC49 A6NMU0, A8KAI9, B2R6L5, B4E1F0, B4E1H2, |
UniProt Related Accession: | P05155 |
Molecular Weight: | |
NCBI Full Name: | Plasma protease C1 inhibitor |
NCBI Synonym Full Names: | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 |
NCBI Official Symbol: | SERPING1 |
NCBI Official Synonym Symbols: | C1IN; C1NH; HAE1; HAE2; C1INH |
NCBI Protein Information: | plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1 |
UniProt Protein Name: | Plasma protease C1 inhibitor |
UniProt Synonym Protein Names: | C1 esterase inhibitor; C1-inhibiting factor; Serpin G1 |
Protein Family: | Para-Rep |
UniProt Gene Name: | SERPING1 |
UniProt Entry Name: | IC1_HUMAN |