RNF126 Antibody, FITC conjugated (PACO49956)
- SKU:
- PACO49956
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | RNF126 Antibody, FITC conjugated (PACO49956) |
抗体コード: | PACO49956 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human E3 ubiquitin-protein ligase RNF126 protein (39-225AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation. May monoubiquitinate AICDA. |
シノニム: | E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126), RNF126 |
UniProt Protein Function: | RNF126: 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; EC 6.3.2.19; Ubiquitin ligase Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; zinc ion binding; epidermal growth factor receptor binding; ligase activity Biological Process: protein monoubiquitination; negative regulation of epidermal growth factor receptor signaling pathway; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; protein ubiquitination during ubiquitin-dependent protein catabolic process; retrograde transport, endosome to Golgi; regulation of cell proliferation |
NCBI Summary: | The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BV68 |
NCBI GenInfo Identifier: | 74762712 |
NCBI Gene ID: | 55658 |
NCBI Accession: | Q9BV68.1 |
UniProt Secondary Accession: | Q9BV68,Q9NWX1, |
UniProt Related Accession: | Q9BV68 |
Molecular Weight: | 311 |
NCBI Full Name: | E3 ubiquitin-protein ligase RNF126 |
NCBI Synonym Full Names: | ring finger protein 126 |
NCBI Official Symbol: | RNF126 |
NCBI Protein Information: | E3 ubiquitin-protein ligase RNF126 |
UniProt Protein Name: | E3 ubiquitin-protein ligase RNF126 |
UniProt Synonym Protein Names: | RING finger protein 126 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RNF126 |
UniProt Entry Name: | RN126_HUMAN |