RGMA Antibody, FITC conjugated (PACO38420)
- SKU:
- PACO38420
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | RGMA Antibody, FITC conjugated (PACO38420) |
抗体コード: | PACO38420 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Repulsive guidance molecule A protein (153-408AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. |
シノニム: | Repulsive guidance molecule A (RGM domain family member A), RGMA, RGM |
NCBI Summary: | This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q96B86 |
NCBI GenInfo Identifier: | 296452979 |
NCBI Gene ID: | 56963 |
NCBI Accession: | Q96B86.3 |
UniProt Related Accession: | Q96B86 |
Molecular Weight: | 72.5 kDa |
NCBI Full Name: | Repulsive guidance molecule A |
NCBI Synonym Full Names: | repulsive guidance molecule BMP co-receptor a |
NCBI Official Symbol: | RGMA |
NCBI Official Synonym Symbols: | RGM |
NCBI Protein Information: | repulsive guidance molecule A |
UniProt Protein Name: | Repulsive guidance molecule A |
UniProt Synonym Protein Names: | RGM domain family member A |
Protein Family: | Repulsive guidance molecule |
UniProt Gene Name: | RGMA |
UniProt Entry Name: | RGMA_HUMAN |