UniProt Protein Function: | PTPN22: Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T-cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases. Interacts with CSK. Interacts with LPXN. Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. Down-regulated by phosphorylation. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48 Chromosomal Location of Human Ortholog: 1p13.2 Cellular Component: cytoplasm; internal side of plasma membrane; nucleus; perinuclear region of cytoplasm Molecular Function:kinase binding; phosphoric monoester hydrolase activity; protein binding; protein tyrosine phosphatase activity; SH3 domain binding; ubiquitin protein ligase binding Biological Process: lipopolysaccharide-mediated signaling pathway; negative regulation of autophagy; negative regulation of JNK activity; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of interferon type I production; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; protein amino acid dephosphorylation; regulation of innate immune response; regulation of natural killer cell proliferation; response to lipopolysaccharide; T cell differentiation Disease: Diabetes Mellitus, Insulin-dependent; Rheumatoid Arthritis; Systemic Lupus Erythematosus |
NCBI Summary: | This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009] |
UniProt Code: | Q9Y2R2 |
NCBI GenInfo Identifier: | 20139861 |
NCBI Gene ID: | 26191 |
NCBI Accession: | Q9Y2R2.2 |
UniProt Secondary Accession: | Q9Y2R2,O95063, O95064, Q6IPX8, Q8WVM1, A0N0K6, B1ALC8 D4NZ71, E9PLD8, E9PPI1, |
UniProt Related Accession: | Q9Y2R2 |
Molecular Weight: | 75,488 Da |
NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 22 |
NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 22 |
NCBI Official Symbol: | PTPN22 |
NCBI Official Synonym Symbols: | LYP; PEP; LYP1; LYP2; PTPN8 |
NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 22 |
UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 22 |
UniProt Synonym Protein Names: | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; LyP; PEST-domain phosphatase; PEP |
Protein Family: | Tyrosine-protein phosphatase non-receptor |
UniProt Gene Name: | PTPN22 |
UniProt Entry Name: | PTN22_HUMAN |