PTPN22 Antibody, Biotin conjugated (PACO62354)
- SKU:
- PACO62354
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | PTPN22 Antibody, Biotin conjugated (PACO62354) |
抗体コード: | PACO62354 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Tyrosine-protein phosphatase non-receptor type 22 protein (1-179AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy. |
シノニム: | Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP), PTPN22, PTPN8 |
UniProt Protein Function: | PTPN22: Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T-cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases. Interacts with CSK. Interacts with LPXN. Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. Down-regulated by phosphorylation. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48 Chromosomal Location of Human Ortholog: 1p13.2 Cellular Component: cytoplasm; internal side of plasma membrane; nucleus; perinuclear region of cytoplasm Molecular Function:kinase binding; phosphoric monoester hydrolase activity; protein binding; protein tyrosine phosphatase activity; SH3 domain binding; ubiquitin protein ligase binding Biological Process: lipopolysaccharide-mediated signaling pathway; negative regulation of autophagy; negative regulation of JNK activity; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; negative regulation of tumor necrosis factor production; positive regulation of interferon type I production; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; protein amino acid dephosphorylation; regulation of innate immune response; regulation of natural killer cell proliferation; response to lipopolysaccharide; T cell differentiation Disease: Diabetes Mellitus, Insulin-dependent; Rheumatoid Arthritis; Systemic Lupus Erythematosus |
NCBI Summary: | This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009] |
UniProt Code: | Q9Y2R2 |
NCBI GenInfo Identifier: | 20139861 |
NCBI Gene ID: | 26191 |
NCBI Accession: | Q9Y2R2.2 |
UniProt Secondary Accession: | Q9Y2R2,O95063, O95064, Q6IPX8, Q8WVM1, A0N0K6, B1ALC8 D4NZ71, E9PLD8, E9PPI1, |
UniProt Related Accession: | Q9Y2R2 |
Molecular Weight: | 75,488 Da |
NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 22 |
NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 22 |
NCBI Official Symbol: | PTPN22 |
NCBI Official Synonym Symbols: | LYP; PEP; LYP1; LYP2; PTPN8 |
NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 22 |
UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 22 |
UniProt Synonym Protein Names: | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; LyP; PEST-domain phosphatase; PEP |
Protein Family: | Tyrosine-protein phosphatase non-receptor |
UniProt Gene Name: | PTPN22 |
UniProt Entry Name: | PTN22_HUMAN |