PRG2 Antibody, FITC conjugated (PACO46128)
- SKU:
- PACO46128
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | PRG2 Antibody, FITC conjugated (PACO46128) |
抗体コード: | PACO46128 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Bone marrow proteoglycan protein (151-195aa) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
シノニム: | Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)], PRG2, MBP |
UniProt Protein Function: | PRG2: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
UniProt Protein Details: | Protein type:Vesicle; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q12 Cellular Component: transport vesicle; extracellular region Molecular Function:heparin binding; carbohydrate binding Biological Process: positive regulation of interleukin-4 production; negative regulation of interleukin-10 production; defense response to bacterium; immune response; defense response to nematode |
NCBI Summary: | The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] |
UniProt Code: | P13727 |
NCBI GenInfo Identifier: | 281185479 |
NCBI Gene ID: | 5553 |
NCBI Accession: | P13727.2 |
UniProt Secondary Accession: | P13727,P81448, Q14227, Q6ICT2, A6XMW0, B2R5I1, |
UniProt Related Accession: | P13727 |
Molecular Weight: | 25kDa |
NCBI Full Name: | Bone marrow proteoglycan |
NCBI Synonym Full Names: | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
NCBI Official Symbol: | PRG2 |
NCBI Official Synonym Symbols: | MBP; BMPG; MBP1 |
NCBI Protein Information: | bone marrow proteoglycan; bone-marrow proteoglycan; proteoglycan 2 preproprotein; natural killer cell activator; eosinophil major basic protein; eosinophil granule major basic protein |
UniProt Protein Name: | Bone marrow proteoglycan |
UniProt Synonym Protein Names: | Proteoglycan 2Eosinophil granule major basic protein; EMBP; MBPAlternative name(s):Pregnancy-associated major basic protein |
Protein Family: | Myelin basic protein |
UniProt Gene Name: | PRG2 |
UniProt Entry Name: | PRG2_HUMAN |