POU3F2 Antibody, Biotin conjugated (PACO46125)
- SKU:
- PACO46125
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | POU3F2 Antibody, Biotin conjugated (PACO46125) |
抗体コード: | PACO46125 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human POU domain, class 3, transcription factor 2 protein (1-443AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity). |
シノニム: | POU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7), POU3F2, BRN2 OCT7 OTF7 |
UniProt Protein Function: | Oct7: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters. Interacts with PQBP1. Expressed specifically in the neuroectodermal cell lineage. Belongs to the POU transcription factor family. Class- 3 subfamily. 3 isoforms of the human protein are produced by alternative initiation. |
UniProt Protein Details: | Protein type:Transcription factor; Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 6q16 Cellular Component: transcription factor complex; nucleus Molecular Function:identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: epidermis development; transcription, DNA-dependent; positive regulation of multicellular organism growth; hypothalamus cell differentiation; regulation of axonogenesis; astrocyte development; myelination in the peripheral nervous system; neuron differentiation; neurohypophysis development; positive regulation of cell proliferation; cerebral cortex radially oriented cell migration; positive regulation of transcription from RNA polymerase II promoter; forebrain ventricular zone progenitor cell division |
NCBI Summary: | This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012] |
UniProt Code: | P20265 |
NCBI GenInfo Identifier: | 51702521 |
NCBI Gene ID: | 5454 |
NCBI Accession: | NP_005595.2 |
UniProt Secondary Accession: | P20265,Q14960, Q86V54, Q9UJL0, |
UniProt Related Accession: | P20265 |
Molecular Weight: | 26,841 Da |
NCBI Full Name: | POU domain, class 3, transcription factor 2 |
NCBI Synonym Full Names: | POU class 3 homeobox 2 |
NCBI Official Symbol: | POU3F2 |
NCBI Official Synonym Symbols: | BRN2; OCT7; OTF7; OTF-7; POUF3; brn-2; oct-7; N-Oct3 |
NCBI Protein Information: | POU domain, class 3, transcription factor 2; brain-2; octamer-binding protein 7; octamer-binding transcription factor 7; brain-specific homeobox/POU domain protein 2; nervous system-specific octamer-binding transcription factor N-Oct-3 |
UniProt Protein Name: | POU domain, class 3, transcription factor 2 |
UniProt Synonym Protein Names: | Brain-specific homeobox/POU domain protein 2; Brain-2; Brn-2; Nervous system-specific octamer-binding transcription factor N-Oct-3; Octamer-binding protein 7; Oct-7; Octamer-binding transcription factor 7; OTF-7 |
Protein Family: | POU domain, class 3, transcription factor |
UniProt Gene Name: | POU3F2 |
UniProt Entry Name: | PO3F2_HUMAN |