POLR3C Antibody, FITC conjugated (PACO40972)
- SKU:
- PACO40972
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | POLR3C Antibody, FITC conjugated (PACO40972) |
抗体コード: | PACO40972 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human DNA-directed RNA polymerase III subunit RPC3 protein (1-534AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. |
シノニム: | DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) (RNA polymerase III 62 kDa subunit) (RPC62), POLR3C |
UniProt Protein Function: | POLR3C: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family. |
UniProt Protein Details: | Protein type:Transcription initiation complex; EC 2.7.7.6; Transferase; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 1q21.1 Cellular Component: cytosol; DNA-directed RNA polymerase III complex; nucleoplasm; nucleus Molecular Function:DNA-directed RNA polymerase activity; protein binding Biological Process: positive regulation of innate immune response; positive regulation of interferon type I production; positive regulation of interferon-beta production; regulation of transcription from RNA polymerase III promoter |
UniProt Code: | Q9BUI4 |
NCBI GenInfo Identifier: | 60393871 |
NCBI Gene ID: | 10623 |
NCBI Accession: | Q9BUI4.1 |
UniProt Secondary Accession: | Q9BUI4,O15317, Q9Y3R6, |
UniProt Related Accession: | Q9BUI4 |
Molecular Weight: | 60,612 Da |
NCBI Full Name: | DNA-directed RNA polymerase III subunit RPC3 |
NCBI Synonym Full Names: | RNA polymerase III subunit C |
NCBI Official Symbol: | POLR3C |
NCBI Official Synonym Symbols: | RPC3; RPC62 |
NCBI Protein Information: | DNA-directed RNA polymerase III subunit RPC3 |
UniProt Protein Name: | DNA-directed RNA polymerase III subunit RPC3 |
UniProt Synonym Protein Names: | DNA-directed RNA polymerase III subunit C; RNA polymerase III 62 kDa subunit; RPC62 |
UniProt Gene Name: | POLR3C |
UniProt Entry Name: | RPC3_HUMAN |