PNOC Antibody (PACO20110)
- SKU:
- PACO20110
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PNOC Antibody (PACO20110) |
抗体コード: | PACO20110 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Synthetic peptide of human PNOC |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20110(PNOC Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20110(PNOC Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | Nociception, a pain response mechanism, occurs in response to stimuli that threaten the integrity of an organism. The first synapses produced as a result of the initiation of nociception are modulated by excitatory amino acid, (glutamate and aspartate) and many peptides (substance P, CGRP, CCK, endogenous opioids). Nociceptin (also designated orphanin FQ) is a neuronal peptide that is similar to opioid peptides. Nociceptin activates KOR-3 (kappa-type opioid receptor, also designated ORL1), a G protein-coupled receptor. Although similar to dynorphin A, a κ opioid peptide, nociceptin functions to make animals hyperreactive to nociceptive stimulations. Nociceptin is also involved in locomotor behavior and may be involved in the modulation of synaptic plasticity in learning and memory. |
シノニム: | prepronociceptin |
UniProt Protein Function: | PNOC: Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Belongs to the opioid neuropeptide precursor family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 8p21 Cellular Component: extracellular region Molecular Function:neuropeptide hormone activity; protein binding; opioid peptide activity Biological Process: synaptic transmission; neuropeptide signaling pathway; sensory perception; signal transduction |
NCBI Summary: | This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015] |
UniProt Code: | Q13519 |
NCBI GenInfo Identifier: | 2494348 |
NCBI Gene ID: | 5368 |
NCBI Accession: | Q13519.1 |
UniProt Related Accession: | Q13519 |
Molecular Weight: | 13kDa; 20kDa |
NCBI Full Name: | Prepronociceptin |
NCBI Synonym Full Names: | prepronociceptin |
NCBI Official Symbol: | PNOC |
NCBI Official Synonym Symbols: | NOP; OFQ; N/OFQ; PPNOC; ppN/OFQ |
NCBI Protein Information: | prepronociceptin |
UniProt Protein Name: | Prepronociceptin |
UniProt Synonym Protein Names: | Orphanin FQ; PPNOC |
Protein Family: | Prepronociceptin |
UniProt Gene Name: | PNOC |
UniProt Entry Name: | PNOC_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |