PLEKHO1 Antibody, FITC conjugated (PACO48636)
- SKU:
- PACO48636
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | PLEKHO1 Antibody, FITC conjugated (PACO48636) |
抗体コード: | PACO48636 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Pleckstrin homology domain-containing family O member 1 protein (143-404AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. |
シノニム: | Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein), PLEKHO1, CKIP1 OC120 |
UniProt Protein Function: | PLEKHO1: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Tumor suppressor Chromosomal Location of Human Ortholog: 1q21.2 Molecular Function:protein binding |
UniProt Code: | Q53GL0 |
NCBI GenInfo Identifier: | 160419242 |
NCBI Gene ID: | 51177 |
NCBI Accession: | Q53GL0.2 |
UniProt Secondary Accession: | Q53GL0,Q336K5, Q8IZ51, Q9NRV3, Q9UL48, |
UniProt Related Accession: | Q53GL0 |
Molecular Weight: | 42,330 Da |
NCBI Full Name: | Pleckstrin homology domain-containing family O member 1 |
NCBI Synonym Full Names: | pleckstrin homology domain containing O1 |
NCBI Official Symbol: | PLEKHO1 |
NCBI Official Synonym Symbols: | JBP; CKIP1; OC120; CKIP-1 |
NCBI Protein Information: | pleckstrin homology domain-containing family O member 1 |
UniProt Protein Name: | Pleckstrin homology domain-containing family O member 1 |
UniProt Synonym Protein Names: | C-Jun-binding protein; JBP; Casein kinase 2-interacting protein 1; CK2-interacting protein 1; CKIP-1; Osteoclast maturation-associated gene 120 protein |
Protein Family: | Pleckstrin homology domain-containing family |
UniProt Gene Name: | PLEKHO1 |
UniProt Entry Name: | PKHO1_HUMAN |