Phospho-PLN (S16/T17) Antibody (PACO04615)
- SKU:
- PACO04615
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | Phospho-PLN (S16/T17) Antibody |
抗体コード: | PACO04615 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | IF:1:200-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from human PLB around the phosphorylation site of S16/T17. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | PLN; PLB; Cardiac phospholamban; PLB |
UniProt Protein Function: | PLB: a heart protein postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. A major substrate for the cAMP-dependent protein kinase. An inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. A key regulator of cardiac diastolic function. Mutations are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Inhibitor Chromosomal Location of Human Ortholog: 6q22.1 Cellular Component: endoplasmic reticulum; membrane; mitochondrion; perinuclear region of cytoplasm; sarcoplasmic reticulum membrane Molecular Function:ATPase binding; ATPase inhibitor activity; enzyme inhibitor activity; identical protein binding; protein binding Biological Process: cytosolic calcium ion homeostasis; negative regulation of ATPase activity; negative regulation of calcium ion transport; negative regulation of catalytic activity; negative regulation of heart rate; regulation of calcium ion transport; regulation of heart contraction; regulation of the force of heart contraction Disease: Cardiomyopathy, Dilated, 1p; Cardiomyopathy, Familial Hypertrophic, 18 |
NCBI Summary: | The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016] |
UniProt Code: | P26678 |
NCBI GenInfo Identifier: | 130774 |
NCBI Gene ID: | 5350 |
NCBI Accession: | P26678.1 |
UniProt Secondary Accession: | P26678,P61016, P61015, P61013, P61014, A4IFH6, |
UniProt Related Accession: | P26678 |
Molecular Weight: | 6,109 Da |
NCBI Full Name: | Cardiac phospholamban |
NCBI Synonym Full Names: | phospholamban |
NCBI Official Symbol: | PLN |
NCBI Official Synonym Symbols: | PLB; CMD1P; CMH18 |
NCBI Protein Information: | cardiac phospholamban |
UniProt Protein Name: | Cardiac phospholamban |
Protein Family: | Cardiac phospholamban |
UniProt Gene Name: | PLN |
UniProt Entry Name: | PPLA_HUMAN |