Phospho-FCGR2B (Tyr292) Antibody (PACO24088)
- SKU:
- PACO24088
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | Phospho-FCGR2B (Tyr292) Antibody (PACO24088) |
抗体コード: | PACO24088 |
サイズ: | 100ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
反応性: | Human |
免疫原: | Peptide sequence around phosphorylation site of tyrosine 292 (I-T-Y(p)-S-L) derived from Human CD32. |
憲法: | Liquid |
ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
精製方法: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from K562 cells treated with PMA using CD32 (Phospho-Tyr292) Antibody.The lane on the right is treated with the antigen-specific peptide. |
バックグラウンド: | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
シノニム: | CD32; FCG2; FCG2B,; LY-17; CDW32 |
NCBI Summary: | The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
UniProt Code: | P31994 |
NCBI GenInfo Identifier: | |
NCBI Gene ID: | 2213 |
NCBI Accession: | |
UniProt Related Accession: | P31994 |
Molecular Weight: | |
NCBI Full Name: | |
NCBI Synonym Full Names: | Fc fragment of IgG receptor IIb |
NCBI Official Symbol: | FCGR2B |
NCBI Official Synonym Symbols: | CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcRII-c |
NCBI Protein Information: | low affinity immunoglobulin gamma Fc region receptor II-b |
UniProt Protein Name: | |
Protein Family: | CD320 antigen |
UniProt Gene Name: |
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