PDZD3 Antibody, Biotin conjugated (PACO37469)
- SKU:
- PACO37469
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | PDZD3 Antibody, Biotin conjugated (PACO37469) |
抗体コード: | PACO37469 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Na(+)/H(+) exchange regulatory cofactor NHE-RF4 protein (42-291AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. |
シノニム: | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4), PDZD3, IKEPP NHERF4 PDZK2 |
UniProt Protein Function: | PDZD3: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell adhesion Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: apical part of cell; brush border; cytosol; subapical complex Molecular Function:guanylate cyclase inhibitor activity; ion channel inhibitor activity; protein binding; protein C-terminus binding Biological Process: negative regulation of cGMP biosynthetic process; receptor guanylyl cyclase signaling pathway; response to toxin |
NCBI Summary: | Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q86UT5 |
NCBI GenInfo Identifier: | 308153467 |
NCBI Gene ID: | 79849 |
NCBI Accession: | Q86UT5.2 |
UniProt Secondary Accession: | Q86UT5,Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3, |
UniProt Related Accession: | Q86UT5 |
Molecular Weight: | 24,105 Da |
NCBI Full Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 |
NCBI Synonym Full Names: | PDZ domain containing 3 |
NCBI Official Symbol: | PDZD3 |
NCBI Official Synonym Symbols: | IKEPP; PDZK2; NHERF4 |
NCBI Protein Information: | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 |
UniProt Protein Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 |
UniProt Synonym Protein Names: | Intestinal and kidney-enriched PDZ protein; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; Sodium-hydrogen exchanger regulatory factor 4 |
Protein Family: | Na(+)/H(+) exchange regulatory cofactor |
UniProt Gene Name: | PDZD3 |
UniProt Entry Name: | NHRF4_HUMAN |