PDE11A Antibody, Biotin conjugated (PACO52809)
- SKU:
- PACO52809
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | PDE11A Antibody, Biotin conjugated (PACO52809) |
抗体コード: | PACO52809 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A protein (42-190AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. |
シノニム: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A), PDE11A |
UniProt Protein Function: | PDE11A: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. Defects in PDE11A are the cause of primary pigmented nodular adrenocortical disease type 2 (PPNAD2). Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. PPNAD2 is characterized by adrenal glands with overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. PPNAD2 leads to Cushing syndrome. Belongs to the cyclic nucleotide phosphodiesterase family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.4.17; Phosphodiesterase; Nucleotide Metabolism - purine; Mitochondrial; EC 3.1.4.35 Chromosomal Location of Human Ortholog: 2q31.2 Cellular Component: cytosol Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Disease: Pigmented Nodular Adrenocortical Disease, Primary, 2 |
NCBI Summary: | The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HCR9 |
NCBI GenInfo Identifier: | 296439264 |
NCBI Gene ID: | 50940 |
NCBI Accession: | Q9HCR9.2 |
UniProt Secondary Accession: | Q9HCR9,Q14CD1, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45 |
UniProt Related Accession: | Q9HCR9 |
Molecular Weight: | 55,700 Da |
NCBI Full Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
NCBI Synonym Full Names: | phosphodiesterase 11A |
NCBI Official Symbol: | PDE11A |
NCBI Official Synonym Symbols: | PPNAD2 |
NCBI Protein Information: | dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
UniProt Protein Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
UniProt Synonym Protein Names: | cAMP and cGMP phosphodiesterase 11A |
Protein Family: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase |
UniProt Gene Name: | PDE11A |
UniProt Entry Name: | PDE11_HUMAN |