PCSK5 Antibody (PACO11114)
- SKU:
- PACO11114
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | PCSK5 Antibody (PACO11114) |
抗体コード: | PACO11114 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human PCSK5 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | proprotein convertase subtilisin/kexin type 5;PCSK5;PC5;PC6;PC6A;SPC6 ; |
UniProt Protein Function: | PCSK5: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2 and CALD1. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.21.-; Protease Chromosomal Location of Human Ortholog: 9q21.3 Cellular Component: Golgi apparatus; extracellular space; Golgi lumen; integral to membrane; secretory granule Molecular Function:peptidase activity; serine-type endopeptidase activity; peptide binding Biological Process: signal peptide processing; nerve growth factor receptor signaling pathway; heart development; respiratory tube development; cytokine biosynthetic process; embryonic skeletal development; peptide hormone processing; viral infectious cycle; proteolysis; limb morphogenesis; peptide biosynthetic process; anterior/posterior pattern formation; nerve growth factor processing; cell-cell signaling; renin secretion into blood stream; protein processing; kidney development; embryonic gut development; embryo implantation |
NCBI Summary: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014] |
UniProt Code: | Q92824 |
NCBI GenInfo Identifier: | 357529585 |
NCBI Gene ID: | 5125 |
NCBI Accession: | Q92824.4 |
UniProt Secondary Accession: | Q92824,Q13527, Q96EP4, F5H2G7, |
UniProt Related Accession: | Q92824 |
Molecular Weight: | 101,649 Da |
NCBI Full Name: | Proprotein convertase subtilisin/kexin type 5 |
NCBI Synonym Full Names: | proprotein convertase subtilisin/kexin type 5 |
NCBI Official Symbol: | PCSK5 |
NCBI Official Synonym Symbols: | PC5; PC6; PC6A; SPC6 |
NCBI Protein Information: | proprotein convertase subtilisin/kexin type 5; subtilase; protease PC6; prohormone convertase 5; proprotein convertase 6; subtilisin/kexin-like protease PC5 |
UniProt Protein Name: | Proprotein convertase subtilisin/kexin type 5 |
UniProt Synonym Protein Names: | Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; hPC6; Subtilisin/kexin-like protease PC5 |
Protein Family: | Proprotein convertase subtilisin/kexin |
UniProt Gene Name: | PCSK5 |
UniProt Entry Name: | PCSK5_HUMAN |