Pcsk5 Antibody, HRP conjugated (PACO28849)
- SKU:
- PACO28849
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | Pcsk5 Antibody, HRP conjugated (PACO28849) |
抗体コード: | PACO28849 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Mouse |
免疫原: | Recombinant Mouse Proprotein convertase subtilisin/kexin type 5 protein (117-452AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors. |
シノニム: | Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6) (Subtilisin/kexin-like protease PC5), Pcsk5 |
UniProt Protein Function: | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014] |
UniProt Code: | Q04592 |
NCBI GenInfo Identifier: | 299523015 |
NCBI Gene ID: | 5125 |
NCBI Accession: | NP_001177411.1 |
UniProt Secondary Accession: | Q04592,Q04592, P41413 |
UniProt Related Accession: | Q04592,Q92824 |
Molecular Weight: | 101,649 Da |
NCBI Full Name: | proprotein convertase subtilisin/kexin type 5 isoform PC6B preproprotein |
NCBI Synonym Full Names: | proprotein convertase subtilisin/kexin type 5 |
NCBI Official Symbol: | PCSK5 |
NCBI Official Synonym Symbols: | PC5; PC6; PC6A; SPC6 |
NCBI Protein Information: | proprotein convertase subtilisin/kexin type 5 |
UniProt Protein Name: | Proprotein convertase subtilisin/kexin type 5 |
UniProt Synonym Protein Names: | Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; hPC6; Subtilisin/kexin-like protease PC5 |
Protein Family: | |
UniProt Gene Name: | PCSK5 |
UniProt Entry Name: |