PCBP1 Antibody (PACO13481)
- SKU:
- PACO13481
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PCBP1 Antibody (PACO13481) |
抗体コード: | PACO13481 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human hnRNP-E1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | poly(rC) binding protein 1;PCBP1;HNRPE1;HNRPX;hnRNP-E1;hnRNP-X ; |
UniProt Protein Function: | hnRNP E1: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. |
UniProt Protein Details: | Protein type:Translation; RNA splicing; RNA-binding Chromosomal Location of Human Ortholog: 2p13-p12 Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane; nucleoplasm Molecular Function:mRNA binding; protein binding; RNA binding; single-stranded DNA binding Biological Process: gene expression; nuclear mRNA splicing, via spliceosome |
NCBI Summary: | This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15365 |
NCBI GenInfo Identifier: | 42560548 |
NCBI Gene ID: | 5093 |
NCBI Accession: | Q15365.2 |
UniProt Secondary Accession: | Q15365,Q13157, Q14975, |
UniProt Related Accession: | Q15365 |
Molecular Weight: | 37,498 Da |
NCBI Full Name: | Poly(rC)-binding protein 1 |
NCBI Synonym Full Names: | poly(rC) binding protein 1 |
NCBI Official Symbol: | PCBP1 |
NCBI Official Synonym Symbols: | HNRPX; HNRPE1; hnRNP-X; HEL-S-85; hnRNP-E1 |
NCBI Protein Information: | poly(rC)-binding protein 1 |
UniProt Protein Name: | Poly(rC)-binding protein 1 |
UniProt Synonym Protein Names: | Alpha-CP1; Heterogeneous nuclear ribonucleoprotein E1; hnRNP E1; Nucleic acid-binding protein SUB2.3 |
Protein Family: | Poly(rC)-binding protein |
UniProt Gene Name: | PCBP1 |
UniProt Entry Name: | PCBP1_HUMAN |