NUMA1 Antibody, HRP conjugated (PACO54031)
- SKU:
- PACO54031
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | NUMA1 Antibody, HRP conjugated (PACO54031) |
抗体コード: | PACO54031 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Nuclear mitotic apparatus protein 1 protein (627-870AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles during symmetric cell divisions, functioning as a tether linking bulk microtubules of the spindle to centrosomes. Also required for proper alignment of the mitotic spindle during asymmetric cell divisions. |
シノニム: | Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen), NUMA1, NMP22 NUMA |
UniProt Protein Function: | NuMA-1: a coiled-coil nuclear protein that is required to establish and maintain mammalian spindle poles. Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. Two human splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13 Cellular Component: spindle pole; nuclear matrix; dendrite; chromosome; cytosol; nucleoplasm; Golgi membrane; cell soma; apical part of cell; spindle microtubule; cytoplasm; spindle; nucleus Molecular Function:protein binding; microtubule binding; structural molecule activity Biological Process: mitosis; meiotic cell cycle; establishment of mitotic spindle orientation; cell division; mitotic cell cycle; G2/M transition of mitotic cell cycle; nuclear organization and biogenesis Disease: Acute Promyelocytic Leukemia |
NCBI Summary: | This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] |
UniProt Code: | Q14980 |
NCBI GenInfo Identifier: | 145559510 |
NCBI Gene ID: | 4926 |
NCBI Accession: | Q14980.2 |
UniProt Secondary Accession: | Q14980,Q14981, Q9BTE9, H0YH75, |
UniProt Related Accession: | Q14980 |
Molecular Weight: | 109,279 Da |
NCBI Full Name: | Nuclear mitotic apparatus protein 1 |
NCBI Synonym Full Names: | nuclear mitotic apparatus protein 1 |
NCBI Official Symbol: | NUMA1 |
NCBI Official Synonym Symbols: | NUMA |
NCBI Protein Information: | nuclear mitotic apparatus protein 1; SP-H antigen; structural nuclear protein; centrophilin stabilizes mitotic spindle in mitotic cells |
UniProt Protein Name: | Nuclear mitotic apparatus protein 1 |
UniProt Synonym Protein Names: | Nuclear matrix protein-22 |
Protein Family: | Nuclear mitotic apparatus protein |
UniProt Gene Name: | NUMA1 |
UniProt Entry Name: | NUMA1_HUMAN |