Anti-NUMA1 Antibody (CAB0527)
- SKU:
- CAB0527
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
抗体名: | Anti-NUMA1 Antibody |
抗体コード: | CAB0527 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human NUMA1 (NP_006176.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:200 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, Mouse kidney |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human NUMA1 (NP_006176.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MTLH ATRG AALL SWVN SLHV ADPV EAVL QLQD CSIF IKII DRIH GTEE GQQI LKQP VSER LDFV CSFL QKNR KHPS SPEC LVSA QKVL EGSE LELA KMTM LLLY HSTM SSKS PRDW EQFE YKIQ AELA VILK FVLD HEDG LNLN EDLE NFLQ KAPV PSTC SSTF PEEL SPPS HQAK REIR FLEL QKVA SSSS GNNF LSGS PASP MGDI LQTP QFQM RRLK KQLA DERS NRDE LELE LAEN RKLL TEKD AQIA MMQQ RIDR LALL NEKQ AASP LEPK ELEE LRDK NESL TMRL HETL KQCQ DLKT EKSQ M |
遺伝子ID: | 4926 |
Uniprot: | Q14980 |
セルラーロケーション: | Chromosome, Cytoplasm, Nucleus matrix, cytoskeleton, spindle pole |
計算された分子量: | 109kDa/200kDa/201kDa/236kDa/238kDa |
観察された分子量: | 238kDa |
同義語: | NUMA1, NMP-22, NUMA |
バックグラウンド: | This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | NuMA-1: a coiled-coil nuclear protein that is required to establish and maintain mammalian spindle poles. Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. Two human splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13 Cellular Component: spindle pole; nuclear matrix; dendrite; chromosome; cytosol; nucleoplasm; Golgi membrane; cell soma; apical part of cell; spindle microtubule; cytoplasm; spindle; nucleus Molecular Function:protein binding; microtubule binding; structural molecule activity Biological Process: mitosis; meiotic cell cycle; establishment of mitotic spindle orientation; cell division; mitotic cell cycle; G2/M transition of mitotic cell cycle; nuclear organization and biogenesis Disease: Acute Promyelocytic Leukemia |
NCBI Summary: | This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] |
UniProt Code: | Q14980 |
NCBI GenInfo Identifier: | 145559510 |
NCBI Gene ID: | 4926 |
NCBI Accession: | Q14980.2 |
UniProt Secondary Accession: | Q14980,Q14981, Q9BTE9, H0YH75, |
UniProt Related Accession: | Q14980 |
Molecular Weight: | 109,279 Da |
NCBI Full Name: | Nuclear mitotic apparatus protein 1 |
NCBI Synonym Full Names: | nuclear mitotic apparatus protein 1 |
NCBI Official Symbol: | NUMA1 |
NCBI Official Synonym Symbols: | NUMA |
NCBI Protein Information: | nuclear mitotic apparatus protein 1; SP-H antigen; structural nuclear protein; centrophilin stabilizes mitotic spindle in mitotic cells |
UniProt Protein Name: | Nuclear mitotic apparatus protein 1 |
UniProt Synonym Protein Names: | Nuclear matrix protein-22 |
Protein Family: | Nuclear mitotic apparatus protein |
UniProt Gene Name: | NUMA1 |
UniProt Entry Name: | NUMA1_HUMAN |
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