NT5E Antibody (PACO21296)
- SKU:
- PACO21296
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | NT5E Antibody (PACO21296) |
抗体コード: | PACO21296 |
サイズ: | 100ul(100ug) |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant protein of human NT5E |
憲法: | Liquid |
ストレージバッファ: | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | Ecto-5nucleotidase (NT5E, also called CD73) is a 70 kDa glycosyl phosphatidylinositol-anchored membrane-bound glycoprotein that catalyzes the hydrolysis of extracellular nucleoside monophosphates into bioactive nucleoside. NT5E catalyzes the terminal step of extracellular adenosine formation from adenosine-monophosphate, therefore driving the regulation of extracellular adenosine levels and the downstream activation of the four G protein-coupled adenosine receptors. Binding of hypoxia-inducible factor (HIF-1) to the NT5E gene promotor leads to upregulation of NT5E during hypoxia. NT5E biological roles span from lymphocyte adhesion, to fibrosis, to regulation of nociception. |
UniProt Protein Function: | NT5E: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Homodimer; disulfide-linked. Belongs to the 5'-nucleotidase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.3.5; Membrane protein, integral; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Phosphatase (non-protein); Membrane protein, GPI anchor; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide Chromosomal Location of Human Ortholog: 6q14-q21 Cellular Component: cell surface; membrane; cytoplasm; plasma membrane Molecular Function:5'-nucleotidase activity; metal ion binding; nucleotide binding Biological Process: pyrimidine nucleoside catabolic process; dephosphorylation; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; adenosine biosynthetic process; negative regulation of inflammatory response; purine nucleotide catabolic process; DNA metabolic process; purine base metabolic process; AMP catabolic process Disease: Calcification Of Joints And Arteries |
NCBI Summary: | The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] |
UniProt Code: | P21589 |
NCBI GenInfo Identifier: | 112825 |
NCBI Gene ID: | 4907 |
NCBI Accession: | P21589.1 |
UniProt Related Accession: | P21589 |
Molecular Weight: | |
NCBI Full Name: | 5'-nucleotidase |
NCBI Synonym Full Names: | 5'-nucleotidase ecto |
NCBI Official Symbol: | NT5E |
NCBI Official Synonym Symbols: | NT; eN; NT5; NTE; eNT; CD73; E5NT; CALJA |
NCBI Protein Information: | 5'-nucleotidase |
UniProt Protein Name: | 5'-nucleotidase |
UniProt Synonym Protein Names: | Ecto-5'-nucleotidase; CD_antigen: CD73 |
UniProt Gene Name: | NT5E |
UniProt Entry Name: | 5NTD_HUMAN |