NSUN2 Antibody, Biotin conjugated (PACO57163)
- SKU:
- PACO57163
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | NSUN2 Antibody, Biotin conjugated (PACO57163) |
抗体コード: | PACO57163 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human tRNA (cytosine(34)-C(5))-methyltransferase protein (432-509AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity. |
シノニム: | tRNA (cytosine(34)-C(5))-methyltransferase (EC 2.1.1.203) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (tRNA (cytosine-5-)-methyltransferase) (tRNA methyltransferase 4 homolog) (hTrm4), NSUN2, SAKI TRM4 |
UniProt Protein Function: | NSUN2: an RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity. Interacts with NPM1 and NCL during interphase. Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA. Defects in NSUN2 are the cause of mental retardation autosomal recessive type 5 (MRT5), a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily. Two human isoforms produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.1.1.203; Methyltransferase; Nucleolus; RNA-binding Chromosomal Location of Human Ortholog: 5p15.31 Cellular Component: cytoplasm; nucleolus; spindle; nucleus Molecular Function:tRNA (cytosine-5-)-methyltransferase activity; tRNA binding Biological Process: mitosis; cell division; tRNA methylation Disease: Mental Retardation, Autosomal Recessive 5 |
NCBI Summary: | This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011] |
UniProt Code: | Q08J23 |
NCBI GenInfo Identifier: | 148887180 |
NCBI Gene ID: | 54888 |
NCBI Accession: | Q08J23.2 |
UniProt Secondary Accession: | Q08J23,Q1HFZ0, |
UniProt Related Accession: | Q08J23 |
Molecular Weight: | 767 |
NCBI Full Name: | tRNA (cytosine(34)-C(5))-methyltransferase |
NCBI Synonym Full Names: | NOP2/Sun RNA methyltransferase family, member 2 |
NCBI Official Symbol: | NSUN2 |
NCBI Official Synonym Symbols: | MISU; MRT5; SAKI; TRM4 |
NCBI Protein Information: | tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine(34)-C(5))-methyltransferase; NOP2/Sun domain family, member 2; tRNA methyltransferase 4 homolog; substrate of AIM1/Aurora kinase B; 5-methycytoisine methyltransferase; NOL1/NOP2/Sun domain family |
UniProt Protein Name: | tRNA (cytosine(34)-C(5))-methyltransferase |
UniProt Synonym Protein Names: | Myc-induced SUN domain-containing protein; Misu; NOL1/NOP2/Sun domain family member 2; Substrate of AIM1/Aurora kinase B; tRNA (cytosine-5-)-methyltransferase; tRNA methyltransferase 4 homolog; hTrm4 |
Protein Family: | tRNA |
UniProt Gene Name: | NSUN2 |
UniProt Entry Name: | NSUN2_HUMAN |