NLRX1 Antibody, FITC conjugated (PACO49804)
- SKU:
- PACO49804
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | NLRX1 Antibody, FITC conjugated (PACO49804) |
抗体コード: | PACO49804 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human NLR family member X1 protein (45-205AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species. |
シノニム: | NLR family member X1 (Caterpiller protein 11.3) (CLR11.3) (Nucleotide-binding oligomerization domain protein 26) (Nucleotide-binding oligomerization domain protein 5) (Nucleotide-binding oligomerization domain protein 9), NLRX1, NOD26 NOD5 NOD9 |
UniProt Protein Function: | NLRX1: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Interacts with MAVS. Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji, and Jurkat cell lines. Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: mitochondrial outer membrane Molecular Function:protein binding; ATP binding Biological Process: viral reproduction; negative regulation of innate immune response; negative regulation of inflammatory response; negative regulation of interleukin-6 production; innate immune response; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interferon type I production; negative regulation of interferon-beta production |
NCBI Summary: | The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013] |
UniProt Code: | Q86UT6 |
NCBI GenInfo Identifier: | 74759406 |
NCBI Gene ID: | 79671 |
NCBI Accession: | Q86UT6.1 |
UniProt Secondary Accession: | Q86UT6,Q7RTR3, Q96D51, Q9H724, A8K6Q1, B3KPK2, B3KTA2 |
UniProt Related Accession: | Q86UT6 |
Molecular Weight: | 975 |
NCBI Full Name: | NLR family member X1 |
NCBI Synonym Full Names: | NLR family member X1 |
NCBI Official Symbol: | NLRX1 |
NCBI Official Synonym Symbols: | NOD5; NOD9; NOD26; DLNB26; CLR11.3 |
NCBI Protein Information: | NLR family member X1; NLR family, X1; NOD-like receptor X1; caterpiller protein 11.3; nucleotide-binding oligomerization domain protein 5; nucleotide-binding oligomerization domain protein 9; nucleotide-binding oligomerization domain protein 26; nucleotid |
UniProt Protein Name: | NLR family member X1 |
UniProt Synonym Protein Names: | Caterpiller protein 11.3; CLR11.3; Nucleotide-binding oligomerization domain protein 26; Nucleotide-binding oligomerization domain protein 5; Nucleotide-binding oligomerization domain protein 9 |
Protein Family: | NLR family |
UniProt Gene Name: | NLRX1 |
UniProt Entry Name: | NLRX1_HUMAN |