NKX3-1 Antibody (PACO10866)
- SKU:
- PACO10866
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | NKX3-1 Antibody (PACO10866) |
抗体コード: | PACO10866 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human NKX3-1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | 234aa,26kd; |
UniProt Protein Function: | NKX3-1: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Interacts with serum response factor (SRF). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation. By androgens and, in the LNCAP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen- independent phase. Highly expressed in the prostate and, at a lower level, in the testis. Belongs to the NK-3 homeobox family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Tumor suppressor; Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 8p21.2Cellular Component: intracellular; nucleusMolecular Function: androgen receptor activity; caspase activator activity; estrogen receptor activity; estrogen receptor binding; histone deacetylase binding; protein binding; protein kinase activator activity; protein self-association; sequence-specific DNA binding; transcription factor activity; transcription factor bindingBiological Process: androgen receptor signaling pathway; branching morphogenesis of a tube; caspase activation; multicellular organismal development; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of mitotic cell cycle; negative regulation of transcription, DNA-dependent; positive regulation of caspase activity; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of mitotic cell cycle; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein kinase B signaling cascade; response to testosterone stimulus; salivary gland development |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012] |
UniProt Code: | Q99801 |
NCBI GenInfo Identifier: | 17377578 |
NCBI Gene ID: | 4824 |
NCBI Accession: | Q99801.2 |
UniProt Secondary Accession: | Q99801,O15465, Q9H2P4, Q9H2P5, Q9H2P6, Q9H2P7, Q9HBG0 |
UniProt Related Accession: | Q99801 |
Molecular Weight: | 21,626 Da |
NCBI Full Name: | Homeobox protein Nkx-3.1 |
NCBI Synonym Full Names: | NK3 homeobox 1 |
NCBI Official Symbol: | NKX3-1 |
NCBI Official Synonym Symbols: | NKX3; BAPX2; NKX3A; NKX3.1 |
NCBI Protein Information: | homeobox protein Nkx-3.1 |
UniProt Protein Name: | Homeobox protein Nkx-3.1 |
UniProt Synonym Protein Names: | Homeobox protein NK-3 homolog A |
Protein Family: | Homeobox protein |
UniProt Gene Name: | NKX3-1 |
UniProt Entry Name: | NKX31_HUMAN |