ERVW-1 Antibody (PACO20633)
- SKU:
- PACO20633
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ERVW-1 Antibody (PACO20633) |
抗体コード: | PACO20633 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Synthetic peptide of human ERVW-1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20633(ERVW-1 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. |
シノニム: | endogenous retrovirus group W, member 1 |
UniProt Protein Function: | ERVWE1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis. Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell surface Chromosomal Location of Human Ortholog: 7q21.2 Biological Process: anatomical structure morphogenesis; syncytium formation |
NCBI Summary: | Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010] |
UniProt Code: | Q9UQF0 |
NCBI GenInfo Identifier: | 47605755 |
NCBI Gene ID: | 30816 |
NCBI Accession: | Q9UQF0.1 |
UniProt Secondary Accession: | Q9UQF0,O95244, O95245, Q8NHY7, Q9NRZ2, Q9NZG3, B2RPD4 |
UniProt Related Accession: | Q9UQF0 |
Molecular Weight: | 59,866 Da |
NCBI Full Name: | Syncytin-1 |
NCBI Synonym Full Names: | endogenous retrovirus group W member 1 |
NCBI Official Symbol: | ERVW-1 |
NCBI Official Synonym Symbols: | ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV |
NCBI Protein Information: | syncytin-1 |
UniProt Protein Name: | Syncytin-1 |
UniProt Synonym Protein Names: | Endogenous retrovirus group W member 1; Env-W; Envelope polyprotein gPr73; Enverin; HERV-7q Envelope protein; HERV-W envelope protein; HERV-W_7q21.2 provirus ancestral Env polyprotein; Syncytin |
Protein Family: | Syncytin |
UniProt Gene Name: | ERVW-1 |
UniProt Entry Name: | SYCY1_HUMAN |
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Anti-ERVW-1 Antibody (CAB16522) |
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