NEO1 Antibody, FITC conjugated (PACO46984)
- SKU:
- PACO46984
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | NEO1 Antibody, FITC conjugated (PACO46984) |
抗体コード: | PACO46984 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Neogenin protein (414-682AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. |
シノニム: | Neogenin (Immunoglobulin superfamily DCC subclass member 2), NEO1, IGDCC2 NGN |
UniProt Protein Function: | NEO1: May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. Belongs to the immunoglobulin superfamily. DCC family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q22.3-q23 Cellular Component: Golgi apparatus; nucleoplasm; plasma membrane Biological Process: iron ion homeostasis |
NCBI Summary: | This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
UniProt Code: | Q92859 |
NCBI GenInfo Identifier: | 116242676 |
NCBI Gene ID: | 4756 |
NCBI Accession: | Q92859.2 |
UniProt Secondary Accession: | Q92859,O00340, Q17RX1, B7ZKM9, B7ZKN0, |
UniProt Related Accession: | Q92859 |
Molecular Weight: | 158,827 Da |
NCBI Full Name: | Neogenin |
NCBI Synonym Full Names: | neogenin 1 |
NCBI Official Symbol: | NEO1 |
NCBI Official Synonym Symbols: | NGN; IGDCC2; NTN1R2 |
NCBI Protein Information: | neogenin |
UniProt Protein Name: | Neogenin |
UniProt Synonym Protein Names: | Immunoglobulin superfamily DCC subclass member 2 |
Protein Family: | Neogenin |
UniProt Gene Name: | NEO1 |
UniProt Entry Name: | NEO1_HUMAN |