MVP Antibody, FITC conjugated (PACO28436)
- SKU:
- PACO28436
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | MVP Antibody, FITC conjugated (PACO28436) |
抗体コード: | PACO28436 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Major vault protein (2-893AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. |
シノニム: | Major vault protein (MVP) (Lung resistance-related protein), MVP, LRP |
UniProt Protein Function: | MVP: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. |
UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; nuclear pore; nucleus; ribonucleoprotein complex Molecular Function:protein binding; protein phosphatase binding; protein kinase binding Biological Process: cell proliferation; protein transport; mRNA transport; negative regulation of protein amino acid autophosphorylation |
NCBI Summary: | This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] |
UniProt Code: | Q14764 |
NCBI GenInfo Identifier: | 21542417 |
NCBI Gene ID: | 9961 |
NCBI Accession: | Q14764.4 |
UniProt Secondary Accession: | Q14764,Q96BG4, Q9BPW6, Q9BQT1, Q9UBD1, |
UniProt Related Accession: | Q14764 |
Molecular Weight: | 893 |
NCBI Full Name: | Major vault protein |
NCBI Synonym Full Names: | major vault protein |
NCBI Official Symbol: | MVP |
NCBI Official Synonym Symbols: | LRP; VAULT1 |
NCBI Protein Information: | major vault protein; lung resistance-related protein |
UniProt Protein Name: | Major vault protein |
UniProt Synonym Protein Names: | Lung resistance-related protein |
Protein Family: | Hyperpolarization-activated voltage-gated potassium channel |
UniProt Gene Name: | MVP |
UniProt Entry Name: | MVP_HUMAN |