MPO Antibody (PACO14718)
- SKU:
- PACO14718
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MPO Antibody (PACO14718) |
抗体コード: | PACO14718 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human MPO |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO14718(MPO Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14718(MPO Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acid, central to the microbicidal activity of netrophils. |
シノニム: | myeloperoxidase |
UniProt Protein Function: | MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 1.11.2.2; Oxidoreductase Chromosomal Location of Human Ortholog: 17q23.1 Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule Molecular Function:heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding Biological Process: respiratory burst during defense response; response to food; removal of superoxide radicals; response to mechanical stimulus; hydrogen peroxide catabolic process; defense response; response to yeast; response to lipopolysaccharide; response to oxidative stress; defense response to fungus; negative regulation of apoptosis; aging Disease: Myeloperoxidase Deficiency; Alzheimer Disease |
NCBI Summary: | Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008] |
UniProt Code: | P05164 |
NCBI GenInfo Identifier: | 129825 |
NCBI Gene ID: | 4353 |
NCBI Accession: | P05164.1 |
UniProt Secondary Accession: | P05164,Q14862, Q4PJH5, Q9UCL7, A1L4B8, |
UniProt Related Accession: | P05164 |
Molecular Weight: | 87,248 Da |
NCBI Full Name: | Myeloperoxidase |
NCBI Synonym Full Names: | myeloperoxidase |
NCBI Official Symbol: | MPO |
NCBI Protein Information: | myeloperoxidase |
UniProt Protein Name: | Myeloperoxidase |
Protein Family: | Myeloperoxidase |
UniProt Gene Name: | MPO |
UniProt Entry Name: | PERM_HUMAN |
Antibodies | ELISA Kits |
Anti-MPO Antibody (CAB1374) | Human Myeloperoxidase (MPO) ELISA Kit |
Cleaved-MPO (A49) Antibody (PACO00055) | |
MPO Antibody (PACO02039) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |