MKI67 Antibody, FITC conjugated (PACO33086)
- SKU:
- PACO33086
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | MKI67 Antibody, FITC conjugated (PACO33086) |
抗体コード: | PACO33086 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Proliferation marker protein Ki-67 protein (3120-3256AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). |
シノニム: | Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67), MKI67 |
UniProt Protein Function: | KI-67: a protein that may be a marker of proliferating cells, involved in chromatin compaction. Its expression is altered in many tumor types including osteosarcomas, histiocytomas, prostate, breast and esophageal cancers. Mutated in colon, cervical and lung cancers. |
UniProt Protein Details: | Protein type:Nucleolus; Cell cycle regulation Chromosomal Location of Human Ortholog: 10q26.2 Cellular Component: chromosome, pericentric region; condensed chromosome; cytoplasm; membrane; nucleolus; nucleus Molecular Function:ATP binding; protein binding; protein C-terminus binding Biological Process: cell proliferation; DNA metabolic process; hyaluronan metabolic process; meiosis; organ regeneration; response to organic cyclic substance |
NCBI Summary: | This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009] |
UniProt Code: | P46013 |
NCBI GenInfo Identifier: | 118572663 |
NCBI Gene ID: | 4288 |
NCBI Accession: | P46013.2 |
UniProt Secondary Accession: | P46013,Q5VWH2, |
UniProt Related Accession: | P46013 |
Molecular Weight: | 319,444 Da |
NCBI Full Name: | Antigen KI-67 |
NCBI Synonym Full Names: | marker of proliferation Ki-67 |
NCBI Official Symbol: | MKI67 |
NCBI Official Synonym Symbols: | KIA; MIB-; MIB-1; PPP1R105 |
NCBI Protein Information: | antigen KI-67 |
UniProt Protein Name: | Antigen KI-67 |
UniProt Gene Name: | MKI67 |
UniProt Entry Name: | KI67_HUMAN |