MEF2D Antibody, FITC conjugated (PACO50480)
- SKU:
- PACO50480
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | MEF2D Antibody, FITC conjugated (PACO50480) |
抗体コード: | PACO50480 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Myocyte-specific enhancer factor 2D protein (299-509AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). |
シノニム: | Myocyte-specific enhancer factor 2D, MEF2D |
UniProt Protein Function: | MEF2D: transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in muscle-specific and/or growth factor-related transcription. Six splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 1q12-q23 Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:histone deacetylase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription activator binding; transcription factor activity Biological Process: adult heart development; apoptosis; chondrocyte differentiation; endochondral ossification; muscle development; nervous system development; osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
NCBI Summary: | This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] |
UniProt Code: | Q14814 |
NCBI GenInfo Identifier: | 2500876 |
NCBI Gene ID: | 4209 |
NCBI Accession: | Q14814.1 |
UniProt Secondary Accession: | Q14814,Q14815, Q5T9U5, Q5T9U6, D3DVC0, |
UniProt Related Accession: | Q14814 |
Molecular Weight: | 49,856 Da |
NCBI Full Name: | Myocyte-specific enhancer factor 2D |
NCBI Synonym Full Names: | myocyte enhancer factor 2D |
NCBI Official Symbol: | MEF2D |
NCBI Protein Information: | myocyte-specific enhancer factor 2D |
UniProt Protein Name: | Myocyte-specific enhancer factor 2D |
Protein Family: | Myocyte-specific enhancer factor |
UniProt Gene Name: | MEF2D |
UniProt Entry Name: | MEF2D_HUMAN |