MAP3K7 Antibody (PACO05170)
- SKU:
- PACO05170
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | MAP3K7 Antibody (PACO05170) |
抗体コード: | PACO05170 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthesized peptide derived from human Tak1 around the non-phosphorylation site of S439. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-β-activated kinase 1; TGF-β-activated kinase 1 |
UniProt Protein Function: | TAK1: a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, TKL; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; TAK1 subfamily Chromosomal Location of Human Ortholog: 6q15 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; endosome membrane; IkappaB kinase complex; nucleus; cytosol Molecular Function:MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK activity; activation of MAPKK activity; apoptosis; activation of MAPK activity; stress-activated MAPK cascade; positive regulation of T cell cytokine production; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; transforming growth factor beta receptor signaling pathway; JNK cascade; angiogenesis; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-2 production; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; positive regulation of T cell activation; I-kappaB phosphorylation; neural tube formation |
NCBI Summary: | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43318 |
NCBI GenInfo Identifier: | 12643557 |
NCBI Gene ID: | 6885 |
NCBI Accession: | O43318.1 |
UniProt Secondary Accession: | O43318,O43317, O43319, Q5TDN2, Q5TDN3, Q5TDT7, Q9NTR3 Q9NZ70, B2RE27, E1P523, |
UniProt Related Accession: | O43318 |
Molecular Weight: | 67,196 Da |
NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 7 |
NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 7 |
NCBI Official Symbol: | MAP3K7 |
NCBI Official Synonym Symbols: | TAK1; MEKK7; TGF1a |
NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1 |
UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 7 |
UniProt Synonym Protein Names: | Transforming growth factor-beta-activated kinase 1 |
Protein Family: | Mitogen-activated protein kinase kinase kinase |
UniProt Gene Name: | MAP3K7 |
UniProt Entry Name: | M3K7_HUMAN |