LRRFIP1 Antibody, Biotin conjugated (PACO28024)
- SKU:
- PACO28024
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | LRRFIP1 Antibody, Biotin conjugated (PACO28024) |
抗体コード: | PACO28024 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Leucine-rich repeat flightless-interacting protein 1 protein (1-315AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. |
シノニム: | Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein), LRRFIP1, GCF2 TRIP |
UniProt Protein Function: | LRRFIP1: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Belongs to the LRRFIP family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; RNA-binding Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cytoskeleton; cytoplasm; plasma membrane; nucleus; cytosol Molecular Function:protein binding; protein homodimerization activity; DNA binding; double-stranded RNA binding Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of interferon type I production; innate immune response; negative regulation of transcription, DNA-dependent |
UniProt Code: | Q32MZ4 |
NCBI GenInfo Identifier: | 212276070 |
NCBI Gene ID: | 9208 |
NCBI Accession: | NP_004726.2 |
UniProt Secondary Accession: | Q32MZ4,O75766, O75799, Q32MZ5, Q53T49, Q6PKG2, Q9Y607 E9PGZ2, |
UniProt Related Accession: | Q32MZ4 |
Molecular Weight: | 73,060 Da |
NCBI Full Name: | leucine-rich repeat flightless-interacting protein 1 isoform 4 |
NCBI Synonym Full Names: | leucine rich repeat (in FLII) interacting protein 1 |
NCBI Official Symbol: | LRRFIP1 |
NCBI Official Synonym Symbols: | GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1 |
NCBI Protein Information: | leucine-rich repeat flightless-interacting protein 1; GC-binding factor 2; NEDD8-conjugating enzyme; TAR RNA-interacting protein; LRR FLII-interacting protein 1 |
UniProt Protein Name: | Leucine-rich repeat flightless-interacting protein 1 |
UniProt Synonym Protein Names: | GC-binding factor 2; TAR RNA-interacting protein |
UniProt Gene Name: | LRRFIP1 |
UniProt Entry Name: | LRRF1_HUMAN |