LIG1 Antibody, Biotin conjugated (PACO27960)
- SKU:
- PACO27960
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | LIG1 Antibody, Biotin conjugated (PACO27960) |
抗体コード: | PACO27960 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human DNA ligase 1 protein (1-919AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. |
シノニム: | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1), LIG1 |
UniProt Protein Function: | LIG1: is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. |
UniProt Protein Details: | Protein type:Ligase; EC 6.5.1.1; DNA repair, damage Chromosomal Location of Human Ortholog: 19q13.2-q13.3 Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; mitochondrion; chromosome; nucleus Molecular Function:DNA binding; DNA ligase activity; metal ion binding; DNA ligase (ATP) activity; ATP binding Biological Process: anatomical structure morphogenesis; mismatch repair; V(D)J recombination; DNA strand elongation during DNA replication; DNA repair; lagging strand elongation; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; telomere maintenance via semi-conservative replication; response to hydrogen peroxide; base-excision repair; nucleotide-excision repair; cell division; transcription-coupled nucleotide-excision repair; double-strand break repair; telomere maintenance via recombination; DNA ligation during DNA repair; nucleotide-excision repair, DNA gap filling; mitotic cell cycle; telomere maintenance; DNA metabolic process |
NCBI Summary: | This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
UniProt Code: | P18858 |
NCBI GenInfo Identifier: | 118773 |
NCBI Gene ID: | 3978 |
NCBI Accession: | P18858.1 |
UniProt Related Accession: | P18858 |
Molecular Weight: | Predicted Band Size: 102kDa |
NCBI Full Name: | DNA ligase 1 |
NCBI Synonym Full Names: | DNA ligase 1 |
NCBI Official Symbol: | LIG1 |
NCBI Protein Information: | DNA ligase 1 |
UniProt Protein Name: | DNA ligase 1 |
UniProt Synonym Protein Names: | DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1 |
UniProt Gene Name: | LIG1 |
UniProt Entry Name: | DNLI1_HUMAN |