LHCGR Antibody, FITC conjugated (PACO27945)
- SKU:
- PACO27945
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Description
抗体名: | LHCGR Antibody, FITC conjugated (PACO27945) |
抗体コード: | PACO27945 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Lutropin-choriogonadotropic hormone receptor protein (27-363AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. |
シノニム: | Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R), LHCGR, LCGR LGR2 LHRHR |
UniProt Protein Function: | LHR: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in LHCGR are a cause of familial male precocious puberty (FMPP); also known as testotoxicosis. In FMPP the receptor is constitutively activated. Defects in LHCGR are the cause of luteinizing hormone resistance (LHR); also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 2p21 Cellular Component: integral to plasma membrane; plasma membrane; endosome Molecular Function:lutropin-choriogonadotropic hormone receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; male gonad development; adenylate cyclase activation; male genitalia development; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of inositol trisphosphate biosynthetic process; luteinizing hormone signaling pathway; cognition Disease: Precocious Puberty, Male-limited; Leydig Cell Hypoplasia, Type I |
NCBI Summary: | This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008] |
UniProt Code: | P22888 |
NCBI GenInfo Identifier: | 281185513 |
NCBI Gene ID: | 3973 |
NCBI Accession: | P22888.4 |
UniProt Secondary Accession: | P22888,Q14751, Q15996, Q9UEW9, |
UniProt Related Accession: | P22888 |
Molecular Weight: | 71,615 Da |
NCBI Full Name: | Lutropin-choriogonadotropic hormone receptor |
NCBI Synonym Full Names: | luteinizing hormone/choriogonadotropin receptor |
NCBI Official Symbol: | LHCGR |
NCBI Official Synonym Symbols: | HHG; LHR; LCGR; LGR2; ULG5; LHRHR; LSH-R; LH/CGR; LH/CG-R |
NCBI Protein Information: | lutropin-choriogonadotropic hormone receptor; hypergonadotropic hypogonadism; lutropin/choriogonadotropin receptor |
UniProt Protein Name: | Lutropin-choriogonadotropic hormone receptor |
UniProt Synonym Protein Names: | Luteinizing hormone receptor; LHR; LSH-R |
Protein Family: | Lutropin-choriogonadotropic hormone receptor |
UniProt Gene Name: | LHCGR |
UniProt Entry Name: | LSHR_HUMAN |