UniProt Protein Function: | LHR: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in LHCGR are a cause of familial male precocious puberty (FMPP); also known as testotoxicosis. In FMPP the receptor is constitutively activated. Defects in LHCGR are the cause of luteinizing hormone resistance (LHR); also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-passCellular Component: extracellular space; lysosome; endoplasmic reticulum; integral to plasma membrane; cytoplasm; plasma membrane; integral to membrane; nucleus; endosome; receptor complexMolecular Function: lutropin-choriogonadotropic hormone receptor activity; identical protein binding; protein homodimerization activity; peptide hormone binding; peptide receptor activity, G-protein coupled; ATPase bindingBiological Process: response to drug; protein targeting to lysosome; central nervous system development; hormone-mediated signaling; adenylate cyclase activation; male gonad development; regulation of steroid biosynthetic process; positive regulation of calcium-mediated signaling; positive regulation of inositol trisphosphate biosynthetic process; luteinizing hormone signaling pathway; arachidonic acid secretion; uterus development; G-protein signaling, coupled to cAMP nucleotide second messenger; ovulation cycle process; G-protein coupled receptor protein signaling pathway; ovarian follicle development; positive regulation of hormone biosynthetic process; development of secondary male sexual characteristics; spermatogenesis; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of release of sequestered calcium ion into cytosol; cognition; female gonad development |
UniProt Protein Details: | |
NCBI Summary: | for both luteinizing hormone and choriogonadotropin; involved in reproductive development and function [RGD, Feb 2006] |
UniProt Code: | P16235 |
NCBI GenInfo Identifier: | 6981160 |
NCBI Gene ID: | 25477 |
NCBI Accession: | NP_037110.1 |
UniProt Secondary Accession: | P16235 |
UniProt Related Accession: | P16235 |
Molecular Weight: | |
NCBI Full Name: | lutropin-choriogonadotropic hormone receptor |
NCBI Synonym Full Names: | luteinizing hormone/choriogonadotropin receptor |
NCBI Official Symbol: | Lhcgr |
NCBI Official Synonym Symbols: | Lhr; LSHR; LSH-R; LH/CG-R |
NCBI Protein Information: | lutropin-choriogonadotropic hormone receptor |
UniProt Protein Name: | Lutropin-choriogonadotropic hormone receptor |
UniProt Synonym Protein Names: | Luteinizing hormone receptor; LSH-R |
Protein Family: | |
UniProt Gene Name: | Lhcgr |
UniProt Entry Name: | LSHR_RAT |