LAIR1 Antibody, FITC conjugated (PACO27895)
- SKU:
- PACO27895
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | LAIR1 Antibody, FITC conjugated (PACO27895) |
抗体コード: | PACO27895 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 protein (22-165AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. |
シノニム: | Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305), LAIR1, CD305 |
UniProt Protein Function: | LAIR-1: an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region called the leukocyte receptor cluster, which contains at least 25 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. |
UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: plasma membrane Molecular Function:protein binding Biological Process: regulation of immune response |
NCBI Summary: | The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
UniProt Code: | Q6GTX8 |
NCBI GenInfo Identifier: | 74736490 |
NCBI Gene ID: | 3903 |
NCBI Accession: | Q6GTX8.1 |
UniProt Related Accession: | Q6GTX8 |
Molecular Weight: | 23,049 Da |
NCBI Full Name: | Leukocyte-associated immunoglobulin-like receptor 1 |
NCBI Synonym Full Names: | leukocyte associated immunoglobulin like receptor 1 |
NCBI Official Symbol: | LAIR1 |
NCBI Official Synonym Symbols: | CD305; LAIR-1 |
NCBI Protein Information: | leukocyte-associated immunoglobulin-like receptor 1 |
UniProt Protein Name: | Leukocyte-associated immunoglobulin-like receptor 1 |
UniProt Synonym Protein Names: | CD_antigen: CD305 |
Protein Family: | Leukocyte-associated immunoglobulin-like receptor |
UniProt Gene Name: | LAIR1 |
UniProt Entry Name: | LAIR1_HUMAN |