KYAT1 Antibody, Biotin conjugated (PACO35345)
- SKU:
- PACO35345
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | KYAT1 Antibody, Biotin conjugated (PACO35345) |
抗体コード: | PACO35345 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Kynurenine--oxoglutarate transaminase 1 protein (1-372AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid, (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. |
シノニム: | Kynurenine--oxoglutarate transaminase 1 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase) (EC 4.4.1.13) (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC 2.6.1.64) (Kynurenine aminotransferase 1) (Kynurenine aminotransferase I) (KATI) (Kynurenine--oxoglutarate transaminase I), KYAT1, CCBL1 |
UniProt Protein Function: | CCBL1: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 4.4.1.13; Lyase; EC 2.6.1.7; Transferase; EC 2.6.1.64 Chromosomal Location of Human Ortholog: 9q34.11 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:glutamine-pyruvate transaminase activity; kynurenine-oxoglutarate transaminase activity; phenylalanine(histidine) transaminase activity; protein binding; protein homodimerization activity; transaminase activity Biological Process: amino acid biosynthetic process; amino acid derivative metabolic process; L-phenylalanine catabolic process; tryptophan catabolic process |
NCBI Summary: | This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q16773 |
NCBI GenInfo Identifier: | 46396284 |
NCBI Gene ID: | 883 |
NCBI Accession: | Q16773.1 |
UniProt Secondary Accession: | Q16773,Q5T275, Q8N191, |
UniProt Related Accession: | Q16773 |
Molecular Weight: | 27,420 Da |
NCBI Full Name: | Kynurenine--oxoglutarate transaminase 1 |
NCBI Synonym Full Names: | kynurenine aminotransferase 1 |
NCBI Official Symbol: | KYAT1 |
NCBI Official Synonym Symbols: | GTK; KAT1; KATI; CCBL1 |
NCBI Protein Information: | kynurenine--oxoglutarate transaminase 1 |
UniProt Protein Name: | Kynurenine--oxoglutarate transaminase 1 |
UniProt Synonym Protein Names: | Cysteine-S-conjugate beta-lyase (EC:4.4.1.13); Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase (EC:2.6.1.64); Kynurenine aminotransferase 1 |
UniProt Gene Name: | KYAT1 |
UniProt Entry Name: | KAT1_HUMAN |