KSR2 Antibody, Biotin conjugated (PACO55597)
- SKU:
- PACO55597
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | KSR2 Antibody, Biotin conjugated (PACO55597) |
抗体コード: | PACO55597 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Kinase suppressor of Ras 2 protein (159-296AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. |
シノニム: | Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1), KSR2 |
UniProt Protein Function: | KSR2: Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein kinase, TKL; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; RAF family Chromosomal Location of Human Ortholog: 12q24.22-q24.23 Cellular Component: cytoplasm; membrane Molecular Function:ATP binding; metal ion binding; protein serine/threonine kinase activity Biological Process: protein amino acid phosphorylation |
UniProt Code: | Q6VAB6 |
NCBI GenInfo Identifier: | 148886599 |
NCBI Gene ID: | 283455 |
NCBI Accession: | Q6VAB6.2 |
UniProt Secondary Accession: | Q6VAB6,Q3B828, Q8N775, A0PJT2, |
UniProt Related Accession: | Q6VAB6 |
Molecular Weight: | 49,607 Da |
NCBI Full Name: | Kinase suppressor of Ras 2 |
NCBI Synonym Full Names: | kinase suppressor of ras 2 |
NCBI Official Symbol: | KSR2 |
NCBI Protein Information: | kinase suppressor of Ras 2 |
UniProt Protein Name: | Kinase suppressor of Ras 2 |
Protein Family: | Kinase suppressor of Ras |
UniProt Gene Name: | KSR2 |
UniProt Entry Name: | KSR2_HUMAN |