KDM4A Antibody (PACO19871)
- SKU:
- PACO19871
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | KDM4A Antibody (PACO19871) |
抗体コード: | PACO19871 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human KDM4A |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19871(KDM4A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: NIH/3T3 cells, mouse liver tissue, Primary antibody: PACO19871(KDM4A Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO19871(KDM4A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. |
シノニム: | lysine (K)-specific demethylase 4A |
UniProt Protein Function: | JMJD2A: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family. |
UniProt Protein Details: | Protein type:EC 1.14.11.-; Demethylase; Oxidoreductase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus Molecular Function:histone demethylase activity; histone demethylase activity (H3-K36 specific); methylated histone residue binding; protein binding; ubiquitin protein ligase binding Biological Process: histone demethylation; negative regulation of autophagy; negative regulation of transcription, DNA-dependent |
NCBI Summary: | This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009] |
UniProt Code: | O75164 |
NCBI GenInfo Identifier: | 308153457 |
NCBI Gene ID: | 9682 |
NCBI Accession: | O75164.2 |
UniProt Secondary Accession: | O75164,Q5VVB1, |
UniProt Related Accession: | O75164 |
Molecular Weight: | 54,697 Da |
NCBI Full Name: | Lysine-specific demethylase 4A |
NCBI Synonym Full Names: | lysine demethylase 4A |
NCBI Official Symbol: | KDM4A |
NCBI Official Synonym Symbols: | JMJD2; JHDM3A; JMJD2A; TDRD14A |
NCBI Protein Information: | lysine-specific demethylase 4A |
UniProt Protein Name: | Lysine-specific demethylase 4A |
UniProt Synonym Protein Names: | JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A |
Protein Family: | Lysine-specific demethylase |
UniProt Gene Name: | KDM4A |
UniProt Entry Name: | KDM4A_HUMAN |