KDM4A Antibody, HRP conjugated (PACO45963)
- SKU:
- PACO45963
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | KDM4A Antibody, HRP conjugated (PACO45963) |
抗体コード: | PACO45963 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Lysine-specific demethylase 4A protein (127-364AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. |
シノニム: | Lysine-specific demethylase 4A (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A), KDM4A, JHDM3A JMJD2 JMJD2A KIAA0677 |
UniProt Protein Function: | JMJD2A: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family. |
UniProt Protein Details: | Protein type:EC 1.14.11.-; Demethylase; Oxidoreductase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus Molecular Function:histone demethylase activity; histone demethylase activity (H3-K36 specific); methylated histone residue binding; protein binding; ubiquitin protein ligase binding Biological Process: histone demethylation; negative regulation of autophagy; negative regulation of transcription, DNA-dependent |
NCBI Summary: | This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009] |
UniProt Code: | O75164 |
NCBI GenInfo Identifier: | 308153457 |
NCBI Gene ID: | 9682 |
NCBI Accession: | O75164.2 |
UniProt Secondary Accession: | O75164,Q5VVB1, |
UniProt Related Accession: | O75164 |
Molecular Weight: | 54,697 Da |
NCBI Full Name: | Lysine-specific demethylase 4A |
NCBI Synonym Full Names: | lysine demethylase 4A |
NCBI Official Symbol: | KDM4A |
NCBI Official Synonym Symbols: | JMJD2; JHDM3A; JMJD2A; TDRD14A |
NCBI Protein Information: | lysine-specific demethylase 4A |
UniProt Protein Name: | Lysine-specific demethylase 4A |
UniProt Synonym Protein Names: | JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A |
Protein Family: | Lysine-specific demethylase |
UniProt Gene Name: | KDM4A |
UniProt Entry Name: | KDM4A_HUMAN |