ITGB1BP1 Antibody, Biotin conjugated (PACO62318)
- SKU:
- PACO62318
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | ITGB1BP1 Antibody, Biotin conjugated (PACO62318) |
抗体コード: | PACO62318 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Integrin beta-1-binding protein 1 protein (1-200AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. |
シノニム: | Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1), ITGB1BP1, ICAP1 |
UniProt Protein Function: | ICAP1: May play a role in the recruitment of beta-1 integrins to the focal contacts during integrin-dependent cell adhesion. Isoform 2 does not bind the integrin cytoplasmic domain-associated protein-1. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 2p25.2 Cellular Component: cytoplasm; cytoskeleton; cytosol; focal adhesion; lamellipodium; nucleus; perinuclear region of cytoplasm; plasma membrane; ruffle Molecular Function:GDP-dissociation inhibitor activity; integrin binding; protein binding; protein complex binding; protein transporter activity Biological Process: activation of protein kinase B; blood vessel endothelial cell proliferation during sprouting angiogenesis; cell migration; cell-matrix adhesion; integrin activation; integrin-mediated signaling pathway; lumen formation; myoblast migration; negative regulation of cell proliferation; negative regulation of focal adhesion formation; negative regulation of protein binding; negative regulation of protein kinase activity; positive regulation of cell proliferation; positive regulation of Notch signaling pathway; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; protein transport; receptor clustering; regulation of blood vessel size; regulation of cell adhesion mediated by integrin; regulation of GTPase activity; substrate-bound cell migration, cell release from substrate |
NCBI Summary: | The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016] |
UniProt Code: | O14713 |
NCBI GenInfo Identifier: | 17366148 |
NCBI Gene ID: | 9270 |
NCBI Accession: | O14713.1 |
UniProt Secondary Accession: | O14713,O14714, Q53RS0, D6W4Y9, |
UniProt Related Accession: | O14713 |
Molecular Weight: | 16,140 Da |
NCBI Full Name: | Integrin beta-1-binding protein 1 |
NCBI Synonym Full Names: | integrin subunit beta 1 binding protein 1 |
NCBI Official Symbol: | ITGB1BP1 |
NCBI Official Synonym Symbols: | ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha |
NCBI Protein Information: | integrin beta-1-binding protein 1 |
UniProt Protein Name: | Integrin beta-1-binding protein 1 |
UniProt Synonym Protein Names: | Integrin cytoplasmic domain-associated protein 1; ICAP-1 |
Protein Family: | Integrin beta-1-binding protein |
UniProt Gene Name: | ITGB1BP1 |
UniProt Entry Name: | ITBP1_HUMAN |