UniProt Protein Function: | IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 16q24.1 Cellular Component: nucleoplasm; cytosol Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; protein binding Biological Process: transcription from RNA polymerase II promoter; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; defense response to bacterium; myeloid cell differentiation; immune response; negative regulation of transcription from RNA polymerase II promoter; defense response to protozoan; phagocytosis Disease: Monocyte And Dendritic Cell Deficiency, Autosomal Recessive; Immunodeficiency 32a |
NCBI Summary: | Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q02556 |
NCBI GenInfo Identifier: | 6016308 |
NCBI Gene ID: | 3394 |
NCBI Accession: | Q02556.2 |
UniProt Secondary Accession: | Q02556,A0AV82, |
UniProt Related Accession: | Q02556 |
Molecular Weight: | Calculated MW: 48kDaObserved MW: 53kDa |
NCBI Full Name: | Interferon regulatory factor 8 |
NCBI Synonym Full Names: | interferon regulatory factor 8 |
NCBI Official Symbol: | IRF8 |
NCBI Official Synonym Symbols: | ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP |
NCBI Protein Information: | interferon regulatory factor 8; interferon consensus sequence binding protein 1 |
UniProt Protein Name: | Interferon regulatory factor 8 |
UniProt Synonym Protein Names: | Interferon consensus sequence-binding protein; H-ICSBP; ICSBP |
Protein Family: | Interferon regulatory factor |
UniProt Gene Name: | IRF8 |
UniProt Entry Name: | IRF8_HUMAN |